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Literature summary extracted from

  • Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
    Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells (2015), Endocrinology, 156, 4312-4324.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 (Bu)2cAMP type 2 iodothyronine deiodinase is significantly stimulated by (Bu)2cAMP Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens Q9C0K2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 HUVEC cell expression of type 2 iodothyronine deiodinase D2, which converts T4 to T3, and TR1 in HUVECs Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 L-thyroxine + reduced acceptor
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 Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

General Information

EC Number General Information Comment Organism
1.21.99.4 physiological function the blockade of iodothyronine deiodinase D2 activity abolishes Akt phosphorylation, Rac activation, and cell migration induced by thyroxine but not by 3,3',5-triiodo-L-thyronine Homo sapiens